FIG. 3.

The ADsubTRS1 mutant causes a decrease in capsid production and a disruption of viral replication centers. Thin-section transmission electron microscopy of fibroblasts infected at an MOI of 0.5 PFU/cell and fixed at 72 h postinfection. Fibroblasts were infected with ADwt (A and B) or ADsubTRS1 (C and D). The nuclear envelope is indicated by arrows, and the arrowheads point to capsids. NIEPs, virions, and DBs are labeled in the cytoplasm (A and C). All images (except for higher magnification insets) are taken at the same magnification. Bars, 1 μm.