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. 2004 Sep;1(2):133–144. doi: 10.1093/ecam/neh030

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© 2004, the authors Evidenced-based Complementary and Alternative Medicine, Vol. 1, Issue 2 © Oxford University Press 2004; all rights reserved. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated.

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Aeroplysinin. The Mediterranean sponge Verongia aerophoba (left) produces the secondary metabolite aeroplysinin (right). This tyrosine kinase inhibitor modulates the recognition system of sponges for fungi. The fungal model compound curdlan, composed of (1→3)-b-D-glucan, interacts with its receptor, the (1→3)-β-D-glucan binding protein (GLUBP), in the S. domuncula system. Controlled by a tyrosine kinase, which can be inhibited by the aeroplysinin, this recognition results in an expression of three genes: one coding for the glucan binding protein precursor (GLUBPp), the second for the fibrinogen-like protein (FIBG) and the third for the epidermal growth factor (EGF)-precursor. While fibrinogen is assumed to be involved in the recognition of fungi, EGF might be involved in the control of proliferation of sponge cells.