Table 2.
Univariable and multivariable analysis.
| Univariable Analysis | Multivariable Analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Odds Ratio |
95 CI LL | 95 CI UL | p value | Odds Ratio |
95 CI LL |
95 CI UL |
p value |
| Gender (M vs F) | 0.35 | 0.06 | 1.68 | 0.2009 | ||||
| Age [years] | 1.03 | 0.98 | 1.10 | 0.2836 | ||||
| Pre- op calcium blocker | 2.31 | 0.20 | 53.10 | 0.5142 | ||||
| Pre- op ACE inhibitor/ARB | 4.50 | 1.03 | 22.98 | 0.0544 | ||||
| Pre- op beta blocker | 0.39 | 0.09 | 1.63 | 0.2045 | ||||
| ASA (4 vs 3) | 0.86 | 0.20 | 3.61 | 0.8326 | ||||
| Chronic renal insufficiency | 1.08 | 0.12 | 10.07 | 0.9449 | ||||
| Previous cardiac surgery | 2.31 | 0.20 | 53.10 | 0.5142 | ||||
| Pre- op EF (TEE) (>50 vs 31–50) |
2.00 | 0.17 | 45.99 | 0.5887 | ||||
| PMH allergy/autoimmune Disease |
4.33 | 0.90 | 25.54 | 0.0788 | ||||
| Hemoglobin pre- op [g/dL] | 0.32 | 0.11 | 0.69 | 0.0157 | 0.32 | 0.08 | 0.78 | 0.0370 |
| WBC count pre- op [109/L] | 0.75 | 0.40 | 1.33 | 0.3341 | ||||
| Platelet count pre- op [109/L] | 1.00 | 0.99 | 1.02 | 0.5729 | ||||
| Pre-induction MAP [mmHg] | 0.97 | 0.92 | 1.02 | 0.2424 | ||||
| Additional valve surgery | 8.36 | 1.61 | 65.89 | 0.0198 | ||||
| CPB time [min] | 1.00 | 0.99 | 1.02 | 0.6479 | ||||
| Crossclamp time [min] | 1.00 | 0.98 | 1.02 | 0.8484 | ||||
| HCA time [min] | 1.06 | 0.95 | 1.20 | 0.2998 | ||||
| NP temp at circ arrest [°C] | 1.34 | 1.08 | 1.75 | 0.0146 | 1.36 | 1.07 | 1.89 | 0.0276 |
| MAP area on-CPB [mmHg*min] | 1.00 | 1.00 | 1.01 | 0.2116 | ||||
| Post- op EF (TEE) (>50 vs 31–50) |
2.40 | 0.50 | 13.79 | 0.2896 | ||||
| Transfusion RBC [units] | 4.71 | 1.53 | 24.07 | 0.0259 | ||||
| Transfusion FFP [units] | 0.96 | 0.69 | 1.31 | 0.7916 | ||||
| Transfusion Platelets [units] | 1.45 | 0.53 | 4.50 | 0.4842 | ||||
| Transfusion Cryoprecipitate [units] |
0.78 | 0.300 | 1.94 | 0.5929 | ||||
| Hemoglobin post- op [g/dL] | 0.97 | 0.40 | 2.30 | 0.9381 | ||||
| WBC count 24h post- op [1000/µl] |
1.07 | 0.90 | 1.30 | 0.4534 | ||||
| WBC count 48h post- op [1000/µl] |
1.08 | 0.93 | 1.29 | 0.3318 | ||||
| Baseline chymase [pg/mg plasma protein] |
1.66 | 1.01 | 3.16 | 0.0745 | ||||
| Delta-chymase target-temp [pg/mg plasma protein] |
1.43 | 1.12 | 2.05 | 0.0193 | ||||
| Delta-IL6 target-temp [pg/mg plasma protein] |
1.60 | 0.20 | 11.41 | 0.5989 | ||||
| Delta-IL6 post-CPB [pg/mg plasma protein] |
1.51 | 0.70 | 4.15 | 0.3202 | ||||
| Delta-IL8 target-temp [pg/mg plasma protein] |
0.97 | 0.31 | 3.44 | 0.9616 | ||||
| Delta-IL8 tost-CPB [pg/mg plasma protein] |
0.96 | 0.65 | 1.41 | 0.8379 | ||||
| Delta-TNFa target-temp [pg/mg plasma protein] |
1.68 | 0.00 | 3683.40 | 0.8898 | ||||
| Delta-TNFa post-CPB [pg/mg plasma protein] |
14.04 | 0.20 | 2571.36 | 0.2519 | ||||
| CD11b target-temp [fold increase over baseline] |
1.19 | 0.28 | 5.36 | 0.8169 | ||||
| CD11b post-CPB [fold increase over baseline] |
0.90 | 0.52 | 1.39 | 0.6318 | ||||
As outcome served an increased chymase response determined at the post-CPB blood draw. Hosmer-Lemeshow goodness-of-fit: Chi-squared, 10; df, 2; p-value=0.10.
ACE: angiotensin converting enzyme; ARB: angiotensin II receptor blocker; ASA: American Society of Anesthesiologists physical status classification system; CA: circulatory arrest; CABG: coronary artery bypass grafting; CPB: cardiopulmonary bypass; Delta-: delta baseline; EF: ejection fraction (determined by transesophageal echocardiography [TEE]); EUROscore: European System for Cardiac Operative Risk Evaluation score; FFP: fresh-frozen plasma; HCA: hypothermic circulatory arrest; MAP: mean arterial pressure; NP temp: nasopharyngeal temperature; PMH: past medical history; NP temp: naspharyngeal temperature; RBC: red blood cell; WBC: white blood cell; 95 CI LL: 95% confidence interval lower limit, 95 CI UL: 95% confidence interval upper limit.