Figure 3. EL9 suppresses the induction of ventricular tachycardia (VT) in R176Q/+ mice.
Representative recordings of surface ECG (lead 2) and intracardiac electrograms after S1–S2 extrastimuli (arrows) revealed sinus rhythm in WT mouse (A), but bidirectional (B) and sustained VT (C) in R176Q/+ mouse treated with vehicle. Treatment with K201 and EL9 suppressed the induction of VT in R176Q/+ mice (D, E). Bar graph summarizing incidence of reproducible VT in each group (F). Numbers indicate mice studied. *P<0.05, **P<0.01.