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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Int J Cardiol. 2016 Oct 29;227:668–673. doi: 10.1016/j.ijcard.2016.10.078

Figure 4. Effects of EL9 on heart rate and ventricular function of R176Q/+ mice.

Figure 4

(A) Representative M-mode echocardiogram tracings obtained from WT, R176Q/+, and R176Q/+ mice treated with EL9 (0.6 μg/kg/hr for 6 days). Summary bar graphs showing no differences among these groups in terms of (B) Ejection fraction (EF), (C) left-ventricular posterior wall-thickness at end-systole (LVPWs), and (D) left-ventricular internal diameter at end-diastole (LVIDd). (E) The change in heart rate (ΔHR %) in WT and R176Q /+ mice treated with metoprolol (10 mg/kg) or EL9 (0.6 μg/kg). **P<0.01 vs pre-injection.