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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Am J Geriatr Psychiatry. 2016 Aug 2;25(1):1–10. doi: 10.1016/j.jagp.2016.08.001

Table 2.

Determinants of Cognition Before and After Antipsychotic Dose Reduction

Before Dose Reduction After Dose Reduction
Model Variable B SE
B 		β P Model B SE
B 		β P
RBANS Total Scale (Primary Analyses)
R2 = 0.21,
F(3,32) =
2.85
p = 0.053		 Age 0.22 0.31 0.12 0.48 R2 = 0.33,
F(3,32)=
5.14
p = 0.005		 −0.13 0.35 −0.06 0.73
PANSS −0.32 0.15 −0.36 0.047a −0.28 0.17 −0.27 0.11
BPND 10.03 5.56 0.29 0.081 16.70 5.42 0.46 0.004b
RBANS Immediate Memory
R2 = 0.29,
F(3,33) =
4.42
p = 0.010		 Age 0.25 0.44 0.10 0.57 R2 = 0.41,
F(3,33) =
7.63
p = 0.001		 0.02 0.39 0.009 0.95
PANSS −0.63 0.22 −0.47 0.007a −0.48 0.19 −0.38 0.018a
BPND 14.59 7.89 0.27 0.073 20.58 6.07 0.46 0.002b
RBANS Visuospatial/Constructional
R2 = 0.01,
F(3,33) =
0.15
p = 0.93		 Age 0.02 0.32 0.01 0.96 R2 = 0.07,
F(3,33) =
0.88
p = 0.46		 −0.11 0.33 −0.07 0.73
PANSS 0.06 0.16 0.07 0.73 −0.07 0.16 −0.08 0.68
BPND 3.16 5.76 0.10 0.59 6.98 5.11 0.23 0.18
RBANS Language
R2 = 0.27,
F(3,33) =
4.06
p = 0.015		 Age −0.40 0.21 −0.32 0.07 R2 = 0.18,
F(3,33) =
2.41
p = 0.09		 −0.44 0.32 −0.24 0.18
PANSS −0.08 0.11 −0.13 0.46 −0.09 0.16 −0.11 0.57
BPND 8.99 3.80 0.35 0.024a 9.08 5.07 0.29 0.08
RBANS Attention
R2 = 0.04,
F(3,32) =
0.48
p = 0.70		 Age 0.11 0.42 0.05 0.80 R2 = 0.21,
F(3,32) =
2.81
p = 0.051		 −0.18 0.43 −0.07 0.69
PANSS −0.23 0.21 −0.21 0.27 −0.21 0.21 −0.17 0.34
BPND 1.83 7.55 0.04 0.81 16.41 6.69 0.39 0.02a
RBANS Delayed Memory
R2 = 0.20,
F(3,33) =
2.70
p = 0.06		 Age 0.63 0.49 0.23 0.21 R2 = 0.28,
F(3,33) =
4.17
p = 0.013		 −0.16 0.45 −0.06 0.72
PANSS −0.58 0.24 −0.42 0.023a −0.36 0.22 −0.28 0.11
BPND 11.15 8.80 0.20 0.21 18.05 7.04 0.39 0.015a

B = parameter estimate; SE B = standard error of B; β = standardized B; BPND = non-displaceable Binding Potential; F = F-test; P = p-value based on a t-test and the degrees of freedom as indicated by the error degrees of freedom of the F-test; PANSS = Positive And Negative Syndrome Scale total score; RBANS = Repeatable Battery for the Assessment of Neuropsychological Status;

a

significant without Bonferroni correction but not significant if Bonferroni correction is applied;

b

significant with or without Bonferroni correction.