Table 3.

Determinants of Change in Cognition with Antipsychotic Dose Reduction

Model	Variable	B	SE B	P	P
Δ RBANS Total Scale
R2 = 0.27, F(4,31) = 2.84 p = 0.04	Age	−0.30	0.17	−0.27	0.09
	Δ PANSS Total Score	−0.32	0.60	−0.09	0.57
	Δ BPND	−10.46	3.85	−0.43	0.011
	Baseline BPND	4.24	3.47	0.20	0.23
Δ Immediate Memory
R2 = 0.10, F(4,32) = 0.89 p = 0.48	Age	−0.10	0.26	−0.07	0.69
	Δ PANSS Total Score	−0.24	0.85	−0.05	0.78
	Δ BPND	−10.15	5.83	−0.30	0.09
	Baseline BPND	3.29	5.37	0.11	0.55
Δ Visuospatial/Constructional
R2 = 0.06, F(4,32) = 0.51 p = 0.73	Age	−0.23	0.24	−0.16	0.35
	Δ PANSS Total Score	0.15	0.82	0.03	0.86
	Δ BPND	−4.92	5.58	−0.16	0.38
	Baseline BPND	−1.40	5.14	−0.05	0.79
Δ Language
R2 = 0.06, F(4,32) = 0.47 p = 0.76	Age	−0.05	0.28	−0.03	0.86
	Δ PANSS Total Score	0.59	0.95	0.11	0.54
	Δ BPND	−3.66	6.50	−0.10	0.58
	Baseline BPND	−4.94	5.99	−0.15	0.42
Δ Attention
R2 = 0.20, F(4,31) = 1.90 p = 0.14	Age	−0.22	0.22	−0.16	0.33
	Δ PANSS Total Score	−0.91	0.72	−0.21	0.22
	Δ BPND	−6.31	5.03	−0.21	0.22
	Baseline BPND	7.90	4.54	0.29	0.09
Δ Delayed Memory
R2 = 0.13, F(4,32) = 1.21 p = 0.33	Age	−0.61	0.35	−0.29	0.09
	Δ PANSS Total Score	−0.06	1.17	0.009	0.96
	Δ BPND	−7.29	8.0	−0.16	0.37
	Baseline BPND	9.16	7.36	0.22	0.22

B = parameter estimate; SE B = standard error of B; β = standardized B; F = F-test; P = p-value based on a t-test and the degrees of freedom as indicated by the error degrees of freedom of the F-test;

Δ= Change; BP_ND = non-displaceable Binding Potential; Baseline BP_ND = BP_ND before dose reduction; PANSS = Positive And Negative Syndrome Scale; RBANS = Repeatable Battery for the Assessment of Neuropsychological Status