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. 2016 Nov 28;198(1):196–204. doi: 10.4049/jimmunol.1600420

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Copyright © 2016 by The American Association of Immunologists, Inc.

This article is distributed under The American Association of Immunologists, Inc., Reuse Terms and Conditions for Author Choice articles.

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FIGURE 7. — DC-derived IL-2 contributes to efficient Ab production following alum immunization. DC-Il2^−/− and DC-Il2^+/− chimeric mice were primed/boosted with alum-adjuvanted OVA. Sera were collected just before boosting (day 14) and 1–2 wk postboosting (days 21 and 28). OD of ELISA measurements of OVA-specific IgG1 (A), IgE (B), IgM (C), and IgG2b (D) Abs upon preimmunization background subtraction are shown. n = 11 mice for DC-Il2^+/− chimeras, n = 14 for DC-Il2^−/− chimeras, from two independent experiments. Error bars represent SEM. *p < 0.05, ***p < 0.001, unpaired two-tailed t test. ns, not significant.