Table 1.
Demographic and clinical data for the included patients.
| Variable∗ | Total (n = 31) |
Successful cases (n = 15) |
Unsuccessful cases (n = 16) |
P value# |
|---|---|---|---|---|
| Age, years, mean (SD) | 74.6 (9.4) | 74.8 (9.6) | 74.4 (9.8) | 0.93 |
| Male, n (%) | 22 (71.0) | 13 (86.7) | 9 (56.3) | 0.113 |
| APACHE II score, median (IQR) | 19.0 (15.0–19.0) | 15.0 (13.5–19.0) | 19.0 (18.0–20.0) | 0.04 |
| SOFA score, mean (SD) | 3.5 (1.1) | 3.1 (0.8) | 3.8 (1.2) | 0.16 |
| Severe sepsis/septic shock, n (%) | 11 (35.5) | 5 (33.3) | 6 (37.5) | 1.0 |
| VAP, n (%) | 10 (32.3) | 4 (26.7) | 6 (37.5) | 0.704 |
| ICU LOS before TGC, day, median (IQR) | 8 (1–13) | 7 (0.5–10.0) | 9 (6.3–14.5) | 0.16 |
|
| ||||
| Comorbidities, n (%) | ||||
| COPD | 16 (51.6) | 7 (46.7) | 9 (56.3) | 0.724 |
| Bronchiectasis | 3 (9.8) | 1 (6.7) | 2 (12.5) | 1.0 |
| CHF | 8 (25.8) | 5 (33.3) | 3 (18.8) | 0.433 |
| Diabetes | 5 (16.1) | 1 (6.7) | 4 (25.0) | 0.333 |
| Cerebral apoplexy | 3 (9.8) | 2 (13.3) | 1 (6.25) | 0.60 |
| Immunosuppressive status | 5 (16.1) | 3 (20.0) | 2 (12.5) | 0.654 |
| Comorbidities >1 | 17 (54.8) | 10 (66.7) | 7 (43.8) | 0.285 |
|
| ||||
| Responsible pathogens, n (%) | ||||
| Acinetobacter baumannii | 21 (67.7) | 9 (60.0) | 12 (75.0) | 0.458 |
| Klebsiella pneumoniae | 5 (16.1) | 3 (20.0) | 2 (12.5) | 0.654 |
| Escherichia coli | 3 (9.7) | 1 (6.7) | 2 (12.5) | 1.0 |
| Stenotrophomonas maltophilia | 2 (6.5) | 0 | 2 (12.5) | 0.484 |
|
| ||||
| Type of initial empiric antibiotics, n (%) | ||||
| Cephalosporin | 4 (12.9) | 1 (6.7) | 3 (18.8) | 0.60 |
| Combination β-lactam/β-lactamase inhibitor | 12 (38.7) | 6 (40.0) | 6 (37.5) | 1.0 |
| Carbapenem | 15 (48.4) | 10 (66.7) | 5 (31.3) | 0.076 |
| Fluoroquinolone | 9 (29.0) | 4 (26.7) | 5 (31.3) | 1.0 |
| Aminoglycoside | 8 (25.8) | 6 (40.0) | 2 (12.5) | 0.113 |
| Glycopeptide | 5 (16.1) | 1 (6.7) | 4 (25.0) | 0.333 |
| Duration of initial treatment with antibiotics, day, median (IQR) | 13 (7–20) | 7 (7–14) | 16 (7–20) | 0.02 |
| Duration of treatment with TGC, day, mean (SD) | 14.3 (2.8) | 12.7 (5.9) | 15.5 (4.2) | 0.51 |
| Microbiological eradication, n (%) | 19 (61.3) | 13 (86.7) | 6 (37.5) | 0.009 |
| ICU mortality, n (%) | 14 (45.2) | 1 (6.7) | 13 (81.3) | 0 |
∗APACHE II: Acute Physiology and Chronic Health Evaluation II, CHF: chronic heart failure, COPD: chronic obstructive pulmonary disease, ICU: intensive care unit, IMV: invasive mechanical ventilation, IQR: interquartile range, TGC: tigecycline, LOS: length of stay, SD: standard deviation, SOFA: Sequential Organ Failure Assessment, and VAP: ventilator-associated pneumonia.
#Successful cases versus unsuccessful cases.