Figure 2.

Amphetamine induces microgliosis in the striatum of WT and MK−/− mice. (a) Photomicrographs are from Iba-1-immunostained striatal sections of saline- (Sal-) or amphetamine- (Amph-) treated animals. (b) The graph represents quantification of data (mean ± SEM) obtained from the counts of Iba-1-positive cells in standardized areas of the striatum. Significant effects of the genotype (F _(1,10) = 4.597, P = 0.05) and treatment (F _(1,10) = 46.12, P < 0.0001) were found. ^∗∗ P < 0.01 and ^∗∗∗ P < 0.001 versus Sal. Scale bar = 200 μm.