Extended Data Table 1. Summary of the model.
| Subunit Name Bovine / Human | Chain | Total residues / range built | Poly-ALA model | Un-modelled residues | % atomic model | TMHs | Cofactors / Notes | |
|---|---|---|---|---|---|---|---|---|
|
C o r e |
51kDa / NDUFV1 | 1 | 445 / 7-438 | - | 1-6, 439-445 | 97.1 | - | FMN N3 (4Fe[51]) |
| 24kDa / NDUFV2 | 2 | 217 / 3-216 | - | 1-2, 217 | 98.6 | - | N1a (2Fe[24]) | |
| 75kDa / NDUFS1 | 3 | 704 / 6-693 | - | 1-5, 694-704 | 97.7 | - | N1b (2Fe[75]) N4 (4Fe[75]C) N5 (4Fe[75]H) |
|
| 49kDa / NDUFS2 | 4 | 430 / 44-430 | - | 1-43 | 90.0 | - | - | |
| 30kDa / NDUFS3 | 5 | 228 / 7-214 | - | 1-6, 215-228 | 91.2 | - | - | |
| PSST / NDUFS7 | 6 | 179 / 25-179 | - | 1-24 | 86.6 | - | N2 (4Fe[PS]) | |
| TYKY / NDUFS8 | 9 | 176 / 1-176 | - | - | 100 | - | N6a (4Fe[TY]1) N6b (4Fe[TY[2) |
|
| ND1 | H | 318 / 1-318 | - | - | 100 | 8 | ||
| ND2 | N | 347 / 1-347 | - | - | 100 | 11 | (antiporter-like) | |
| ND3 | A | 115 / 1-115 | - | - | 100 | 3 | ||
| ND4 | M | 459 / 1-459 | - | - | 100 | 14 | (antiporter-like) | |
| ND4L | K | 98 / 1-86 | - | 87-98 | 87.8 | 3 | ||
| ND5 | L | 606 / 1-568 | 509-598 | 599-606 | 84.0 | 16 | (antiporter-like) | |
| ND6 | J | 175 / 1-108, 123-175 | 77-122 | - | 73.7 | 5 | - | |
|
S u p e r n u m e r a r y |
10kDa / NDUFV3 | a | 75 / 34-74 | - | 1-33, 75 | 54.7 | - | - |
| 13kDa / NDUFS6 | b | 96 / 1-95 | - | 96 | 99.0 | - | Zn2+ | |
| 18kDa / NDUFS4 | c | 133 / 11-133 | - | 1-10 | 92.5 | - | - | |
| 39kDa / NDUFA9 | d | 345 / 1-252, 277-338 | 325-338 | 253-276, 339-345 | 87.0 | - | NADPH | |
| B8 / NDUFA2 | e | 98 / 13-96 | - | 1-12, 97-98 | 85.7 | - | Thioredoxin fold | |
| B13 / NDUFA5 | f | 115 / 4-115 | - | 1-3 | 97.4 | - | - | |
| B14 / NDUFA6 | g | 127 / 14-127 | - | 1-13 | 89.8 | - | LYR protein | |
| B14.5a / NDUFA7 | h | 112 / 1-71, 89-112 | - | 72-88 | 84.8 | - | - | |
| B17.2 / NDUFA12 | i | 145 / 1-144 | - | 145 | 99.3 | - | - | |
| SDAP-α / NDUFAB1 | j | 88/ 3-87 | - | 1-2, 88 | 96.6 | - | Acyl carrier protein phosphopantetheine | |
| 42kDa / NDUFA10 | k | 320 / 1-320 | 227-320 | - | 70.9 | - | Nucleoside kinase family | |
| 15kDa / NDUFS5 | l | 105 / 1-95 | - | 96-105 | 90.5 | - | Quadruple CX9C 2 CHCH domains | |
| B9 / NDUFA3 | m | 83 / 4-83 | - | 1-3 | 96.4 | 1 | STMD | |
| B12 / NDUFB3 | n | 97 / 13-86 | 83-86 | 1-12, 87-97 | 73.2 | 1 | STMD | |
| B14.5b / NDUFC2 | o | 120 / 1-120 | - | - | 100 | 2 | - | |
| B15 / NDUFB4 | p | 128 / 17-73, 95-128 | 17-27, 74-94 | 1-16 | 62.5 | 1 | STMD | |
| B16.6 / NDUFA13 | q | 143 / 4-143 | - | 1-3 | 97.9 | 1 | Identical to GRIM-19, STMD | |
| B17 / NDUFB6 | r | 127 / 1-37, 63-118 | 63-71 | 38-62, 119-127 | 66.1 | 1 | STMD | |
| B18 / NDUFB7 | s | 136 / 5-122 | 5-15 | 1-4, 123-136 | 78.7 | - | Double Cx9C CHCH domain | |
| B22 / NDUFB9 | t | 178 / 9-174 | - | 1-8, 175-178 | 93.3 | - | LYR protein | |
| AGGG / NDUFB2 | u | 72 / 3-68 | - | 1-2, 69-72 | 91.7 | 1 | STMD | |
| ASHI / NDUFB8 | v | 158 / 1-84, 101-143 | 1-100 | 144-158 | 27.2 | 1 | STMD | |
| ESSS / NDUFB11 | w | 125 / 38-123 | - | 1-37, 124-125 | 68.8 | 1 | STMD | |
| KFYI / NDUFC1 | x | 49 / 1-48 | - | 49 | 98.0 | 1 | STMD | |
| MNLL / NDUFB1 | y | 57 / 4-56 | - | 1-3, 57 | 93.0 | 1 | STMD | |
| MWFE / NDUFA1 | z | 70 / 2-70 | - | 1 | 98.6 | 1 | STMD | |
| PDSW / NDUFB10 | Z | 175 / 3-173 | - | 1-2, 174-175 | 97.7 | - | - | |
| PGIV / NDUFA8 | Y | 171 / 1-171 | - | - | 100 | - | Quadruple CX9C 2 CHCH domains | |
| SDAP-β / NDUFAB1 | X | 88 / 1-88 | - | - | 100 | - | Acyl carrier protein phosphopantetheine | |
| SGDH / NDUFB5 | W | 143 / 5-143 | - | 1-4 | 97.2 | 1 | STMD | |
| B14.7 / NDUFA11 | V | 140 / 7-125 | 7-125 | 21 | 0 | 4 | - | |
| Total | 8516 / 8037 | 518 | 479 | 88.3 | 78 |