Table 2.
MIC values in μg/mLa and (μM) for compounds 3A,B, 4A,C-H, 7Aa-Ag, and 8Aa against various C. albicans strains.
| C. albicans ATCC strain # | |||||||
|---|---|---|---|---|---|---|---|
| Cpd | 1003a | 1237b | 2310c | 2876c | 10231b | 64124b | 90819b |
| AmB | 3.9 (4.2) | 3.9 (4.2) | 3.9 (4.2) | 3.9 (4.2) | 3.9 (4.2) | 2.0-3.9 (2.1-4.2) | 2.0 (2.1) |
| 3A | 7.8 (19.7) | 15.6 (39.5) | >31.3 (>79.2) | 7.8 (19.7) | 15.6 (39.5) | >31.3 (>79.2) | >31.3 (>79.2) |
| 3B | 3.9 (9.9) | 3.9 (9.9) | 3.9 (9.9) | 3.9 (9.9) | 3.9 (9.9) | 3.9 (9.9) | 3.9 (9.9) |
| 4A | 7.8 (18.4) | >31.3 (>73.9) | 3.9 (9.2) | 2.0 (4.7) | 2.0-3.9 (4.7-9.2) | 2.0 (4.7) | 3.9 (9.2) |
| 4C | 7.8 (17.8) | 7.8 (17.8) | 7.8 (17.8) | 3.9 (8.9) | 7.8 (17.8) | 7.8 (17.8) | 7.8 (17.8) |
| 4D | 15.6 (34.6) | 15.6 (34.6) | 31.3 (69.3) | 3.9 (8.6) | 7.8 (17.3) | >31.3 (>69.3) | 7.8 (17.3) |
| 4E | 7.8 (17.8) | 7.8 (17.8) | 7.8 (17.8) | 3.9 (8.9) | 7.8 (17.8) | 7.8 (17.8) | 7.8 (17.8) |
| 4F | 1.0 (2.3) | 2.0 (4.6) | 1.0 (2.3) | 1.0 (2.3) | 1.0-2.0 (2.3-4.6) | 1.0 (2.3) | 2.0 (4.6) |
| 4G | >31.3 (>90.1) | >31.3 (>90.1) | >31.3 (>90.1) | >31.3 (>90.1) | >31.3 (>90.1) | 31.3 (90.1) | >31.3 (>90.1) |
| 4H | >31.3 (>90.1) | 31.3 (90.1) | 31.3 (90.1) | 7.8 (22.5) | >31.3 (>90.1) | >31.3 (>90.1) | >31.3 (>90.1) |
| 7Aa | 2.0 (4.6) | 3.9 (9.2) | 2.0 (4.6) | 2.0 (4.6) | 2.0 (4.6) | 3.9 (9.2) | 2.0 (4.6) |
| 7Ab | 2.0 (4.1) | 3.9 (8.3) | 3.9 (8.3) | 3.9 (8.3) | 2.0 (4.1) | 3.9 (8.3) | 3.9 (8.3) |
| 7Ac | 2.0 (4.7) | 7.8 (19.0) | 3.9 (9.5) | 3.9 (9.5) | 7.8 (19.0) | 31.3 (76.2) | 3.9 (9.5) |
| 7Ad | 3.9 (9.1) | 15.6 (36.5) | 3.9 (9.1) | 7.8 (18.3) | 7.8 (18.3) | 15.6 (36.5) | 7.8 (18.3) |
| 7Ae | 7.8 (18.7) | 15.6 (37.3) | 15.6 (37.3) | 15.6 (37.3) | 15.6 (37.3) | 31.3 (74.9) | 15.6 (37.3) |
| 7Af | 2.0 (4.5) | 3.9 (9.1) | 3.9 (9.1) | 3.9 (9.1) | 1.0 (2.3) | 3.9 (9.1) | 7.8 (18.2) |
| 7Ag | 7.8 (16.8) | 15.6 (33.8) | 7.8 (16.8) | 15.6 (33.8) | 7.8 (16.8) | 31.3 (67.8) | 31.3 (67.8) |
| 8Aa | 15.6 (34.3) | 15.6 (34.3) | 15.6 (34.3) | 15.6 (34.3) | 15.6 (34.3) | 31.3 (68.7) | 15.6 (34.3) |
a
These antifungal MIC values were determined originally in μg/mL using a range of 0.5 to 31.3 μg/mL. The values in μM into parentheses are presented for comparison with the antibacterial MIC values, which were determined originally in μM.
b
Indicates strains that are resistant to FLC, ITC, and VOR according to ATCC.
c
Indicates strains that are susceptible to FLC, ITC, and VOR according to ATCC.
Control antifungal agent: AmB = amphotericin B.