Table 3.
The cytotoxicity (IC50, μg/mL) of selected bis(N-amidinohydrazones) and N-(amidino)-N′-aryl-bishydrazones against A549 and BEAS-2B cell lines. Values are presented as mean ± SDEV.
| Mammalian cell line | ||
|---|---|---|
| Cpd | A549 | BEAS-2B |
| AmB | 18.2 ± 4.5 | 17.7 ± 6.4 |
| 3A | 6.6 ± 1.7 | 3.0 ± 0.7 |
| 3B | 13.9 ± 4.1 | 5.7 ± 1.8 |
| 4A | 6.3 ± 2.2 | 1.7 ± 0.5 |
| 4C | 4.3 ± 1.3 | 2.9 ± 0.9 |
| 4D | 2.9 ± 0.9 | 1.8 ± 0.6 |
| 4E | 3.9 ± 0.9 | 2.9 ± 0.9 |
| 4F | 2.5 ± 1.4 | 1.8 ± 0.6 |
| 4H | 31.2 ± 7.2 | 33.0 ± 4.6 |
| 7Aa | 2.8 ± 0.9 | 2.3 ± 1.0 |
| 7Ab | 6.7 ± 2.3 | 3.4 ± 1.3 |
| 7Ac | 4.4 ± 1.4 | 6.0 ± 1.2 |
| 7Ad | 4.9 ± 1.1 | 6.0 ± 1.1 |
| 7Ae | 4.2 ± 1.4 | 1.9 ± 0.8 |
| 7Af | 4.8 ± 1.3 | 5.8 ± 1.2 |