Table 2. Comparisons of levels of perioperative CA125 by category of surgery outcome.
| CA125 by category of surgery outcome | Descriptive | Comparisons | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CA125, in U/mL | Loge CA125 | Model 1 | Model 2 | ||||||
| Geometric mean (95% CI) | Mean (SD) | ß | 95% CI | p-value | ß | 95% CI | p-value | ||
| Preoperative | |||||||||
| Inadequate (n=43) | 908 (569–1,450) | 6.81 (1.52) | - | - | - | - | - | - | |
| Optimal (n=47) | 610 (433–859) | 6.41 (1.52) | −0.40 | −0.98, 0.18 | 0.181 | −0.36 | −0.93, 0.24 | 0.226 | |
| Complete (n=33) | 460 (264–800) | 6.13 (1.57) | −0.68 | −1.32, −0.04 | 0.037 | −0.68 | −1.31, −0.05 | 0.035 | |
| Linear trend | 0.034 | Linear trend | 0.033 | ||||||
| Postoperative | |||||||||
| Inadequate (n=43) | 341 (229–508) | 5.83 (1.29) | - | - | - | - | - | - | |
| Optimal (n=47) | 170 (133–219) | 5.14 (0.56) | −0.70 | −1.17, −0.24 | 0.003 | −0.69 | −1.16, −0.23 | 0.004 | |
| Complete (n=33) | 118 (76–182) | 4.76 (1.28) | −1.06 | −1.57, −0.55 | <0.001 | −1.06 | −1.57, −0.55 | <0.001 | |
| Linear trend | <0.001 | Linear trend | <0.001 | ||||||
| Decline (pre-postoperative) | |||||||||
| Inadequate (n=43) | 522 (283–508) | 6.26 (1.89) | - | - | - | - | - | - | |
| Optimal (n=47) | 420 (271–650) | 6.04 (1.44) | −0.18 | −0.91, 0.57 | 0.652 | −0.17 | −0.92, 0.58 | 0.654 | |
| Complete (n=33) | 335 (166–678) | 5.82 (1.88) | −0.44 | −1.26, 0.37 | 0.287 | −0.44 | −1.27, 0.39 | 0.301 | |
| Linear trend | 0.289 | Linear trend | 0.303 | ||||||
Model 1, crude (i.e. unadjusted); Model 2, adjusted for potential confounders (i.e. patient’s age and time elapsed between preoperative CA125 assessment and surgery in comparisons of preoperative CA125; time between surgery and postoperative CA125 assessment in comparisons of postoperative CA125; both times in comparisons of perioperative decline in CA125). ß is the regression coefficient indicating the difference in preoperative CA125, postoperative CA125 and perioperative decline in (pre-post) CA125 in complete or optimal versus inadequate (referent) groups; note that because comparisons were performed on loge CA125 data the regression coefficient may need to be back transformed (by taking the anti-log of ß) for a more direct interpretation of the magnitude of the differences, which will then be expressed in percentage difference, i.e. (eß-1)*100; for instance, a ß of −0.40 indicates that the preoperative CA levels were 33% lower in the optimal vs. the inadequate groups.
SD, standard deviation; CI, confidence interval.