Table 3. Determinants of disease specific mortality.
| Determinants | Events/N | Model 1 (unadjusted) | Model 2 (age-adjusted) | Model 3 (fully adjusted) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |||
| Age (per 10 yr) | - | 1.04 | 0.83, 1.30 | 0.742 | - | - | - | 1.08 | 0.83, 1.40 | 0.568 | |
| Decline in CA125 | <0.001 | ||||||||||
| <50%* | 30/41 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| 50%–79% | 22/42 | 0.59 | 0.34, 1.05 | 0.071 | 0.58 | 0.33, 1.02 | 0.059 | 0.52 | 0.28, 0.96 | 0.036 | |
| ≥80% | 15/40 | 0.35 | 0.19, 0.67 | 0.001 | 0.34 | 0.18, 0.65 | 0.001 | 0.26 | 0.13, 0.54 | 0.001 | |
| Histology | |||||||||||
| Other | 26/40 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| Serous | 41/83 | 0.62 | 0.37, 1.02 | 0.062 | 0.61 | 0.37, 1.02 | 0.061 | 0.46 | 0.26, 0.81 | 0.007 | |
| Tumor grade | 0.687 | ||||||||||
| 1 or 2 | 19/33 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| 3 | 33/65 | 0.96 | 0.53, 1.75 | 0.896 | 0.94 | 0.52, 1.72 | 0.851 | 1.11 | 0.59, 2.08 | 0.810 | |
| Unknown | 15/25 | 0.85 | 0.43, 1.69 | 0.644 | 0.81 | 0.40, 1.66 | 0.568 | 1.01 | 0.53, 1.94 | 0.972 | |
| FIGO | |||||||||||
| IV | 17/24 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| III | 49/89 | 0.71 | 0.40, 1.26 | 0.240 | 0.71 | 0.40, 1.25 | 0.236 | 1.01 | 0.53, 1.94 | 0.972 | |
| II | 1/10 | 0.09 | 0.01, 0.72 | 0.022 | 0.09 | 0.01, 0.72 | 0.023 | 0.17 | 0.02, 1.44 | 0.104 | |
| Ascites | 0.710 | ||||||||||
| None | 16/34 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| 0–1,000 | 10/27 | 0.80 | 0.35, 1.80 | 0.586 | 0.80 | 0.35, 1.81 | 0.792 | 0.75 | 0.32, 1.77 | 0.509 | |
| >1,000 | 34/51 | 1.41 | 0.76, 2.60 | 0.277 | 1.41 | 0.76, 2.60 | 0.277 | 1.33 | 0.67, 2.64 | 0.413 | |
| Unknown | 7/11 | 1.10 | 0.45, 2.70 | 0.747 | 1.10 | 0.45, 2.60 | 0.828 | 0.81 | 0.31, 2.15 | 0.675 | |
| Extensive surgery | |||||||||||
| No | 41/75 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| Yes | 26/48 | 0.98 | 0.59, 1.62 | 0.927 | 0.98 | 0.59, 1.62 | 0.924 | 0.80 | 0.47, 1.38 | 0.427 | |
| Surgery outcome | |||||||||||
| Inadequate | 30/43 | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | |
| Optimal | 26/47 | 0.70 | 0.41, 1.20 | 0.201 | 0.72 | 0.42, 1.23 | 0.225 | 0.81 | 0.44, 1.50 | 0.509 | |
| Complete | 11/33 | 0.35 | 0.17, 0.71 | 0.003 | 0.34 | 0.17, 0.69 | 0.003 | 0.52 | 0.23, 1.22 | 0.133 | |
Model 1, crude (i.e. unadjusted); Model 2, adjusted for age; Model 3, fully adjusted model (i.e. model 2 + all determinants considered).
HR, hazard ratio (vs. referent category as indicated by HR=1.00); CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics.
*Includes 10 patients in whom no changes or slight increases in CA125 were observed between pre- and postoperative.