Table 1. Locations, base changes, and allele frequencies of variable loci within the α_2CAR gene.

				Minor allele frequency
Region	Location code	Nucleotide	Alleles	Ca	AA	As
Promoter	a	−2579	T/C	8.8	6.3	35.4
	b	−2416	C/G	0	10.0	0
	c	−2357	C/T	0	10.0	0
	d	−2280	G/T	0	5.0	0
	e	−2069	C/T	7.5	2.5	35.4
	f	−2064	C/T	0	0	2.1
	g	−1926	G/A	1.3	1.3	2.1
	h	−1692	T/G	6.3	38.8	8.3
	i	−1513	T/G	2.5	0	0
	j	−1262	C/A	0	7.5	0
	k	−965	G/C	0	11.3	0
	l	−940	G/A	7.5	2.5	35.4
	m	−933	C/A	1.3	1.3	2.1
5′ UTR	n	−696	C/G	11.3	0	0
	o	−241	C/G	0	7.5	0
	p	−230	T/C	5.0	2.5	6.3
Coding	q	+964 to +975	Ins/Del	6.3	42.5	12.5
3′ UTR	r	+1483 to +1503	Ins/Del	8.8	5.0	42.5
	s	+1486	T/C*	34.2	71.1	30.4
	t	+1757	G/C	31.3	67.5	20.8

Ca, Caucasian; AA, African-American; As, Asian; Ins, insertion; Del, deletion.

^*SNP at s is located within the insertion sequence site r only, so in the deletion form of r, the s genotype is not applicable.