Table 2.
Genes selected.
| Gene | Function | |
|---|---|---|
| 1 | OAS1 | Induced by INF, essential innate immune response protein, member of the 2-5A synthase family |
| 2 | OAS2 | Induced by INF, essential innate immune response protein, member of the 2-5A synthase family |
| 3 | OAS3 | Induced by INF, essential innate immune response protein, member of the 2-5A synthase family |
| 4 | IL15RA | Binds specifically to IL15 (1993, Mammalian Genome 4 (8): 435-9) |
| 5 | TLR3 | Pathogen pattern recognition receptor; binds to dsRNA |
| 6 | TLR4 | Pathogen pattern recognition receptor; binds to LPS |
| 7 | TLR7 | Pathogen pattern recognition receptor; binds to ssRNA |
| 8 | TLR8 | Pathogen pattern recognition receptor; binds to ssRNA |
| 9 | TLR9 | Pathogen pattern recognition receptor; binds to DNA |
| 10 | KIR2DL1 | Inhibitory receptor, HLA-C alleles ligand |
| 11 | KIR2DL3 | Inhibitory receptor, HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7) ligands |
| 12 | KIR2DL4 | Inhibitory receptor, expressed in endosome, HLA-G ligand (Front Immunol. 2012 Aug 20; 3:258. doi: 10.3389/fimmu.2012.00258. eCollection 2012) |
| 13 | KIR2DS4 | Activation receptor; HLA-Cw4 ligand |
| 14 | KIR3DL1 | Inhibitory receptor; HLA Bw4 ligand |
| 15 | KIR3DL2 | Inhibitory receptor; HLA-A ligand |
| 16 | KIR3DL3 | Inhibitory receptor, ligand unknown (Korean J Hematol. 2011 Dec; 46(4): 216-28. Doi) |
| 17 | IRF7 | Activates transcription of INF; exclusively expressed in lymphoid tissue |
| 18 | TRIM5 | Retrovirus restriction factor; binds to virus capsid and presents uncoating |
| 19 | TRIM21 | Involved into intracellular antibody mediated proteolysis |
| 20 | RANSEL | Interferon-induced ribonuclease; degrade RNA cellular and viral |
| 21 | MYD88 | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway |
| 22 | TRIF | TLR adaptor protein |
| 23 | TRAF6 | Member of the TNF receptor associated factor; TLR adaptor protein |