Figure 3.
A simplified scheme showing mechanisms of resveratrol protection against the development of diabetic complications. SIRT1, sirtuin-1; AMPK, adenosine monophosphate activated kinase; Glu, glucose; AGEs, advanced glucose end-products; ∙O2 −, superoxide anion; ∙OH, Hydroxide radical; H2O2, hydrogen peroxide; MDA, malondialdehyde; 8-OHdG, 8-hydroxydeoxyguanine; Nrf2, nuclear factor erythroid 2-related factor 2; SOD, superoxide dismutase; CAT, catalase; GSH, reduced glutathione; GST, glutathione S-transferase; GPx, glutathione peroxidase; NF-κB, nuclear factor-kappa B; IL, interleukin; TNF, tumour necrosis factor; MCP, monocyte chemoattractant protein; Bcl2, B-cell lymphoma 2; Bad, Bcl-2-associated death promoter; Bax, bcl-2-like protein 4.