FIG 1.

Levels of EBV gp350-binding immunoglobulin (IgG) during AIM, CONV, and chronic EBV infection. IgG was isolated from the serum of 24 patients during primary EBV infection (AIM) and 6 months later (during CONV). Binding of gp350 was compared to that in 12 age-matched chronically infected individuals (CHRON) and 12 age-matched EBV-seronegative individuals (Sero NEG). Binding of total patient IgG, as well as that of each IgG subclass, to EBV B95.8 gp350 (aa 4 to 440), was determined by detection of fluorescently labeled secondary antibodies. % Pos, percentage of individuals who were positive (indicated on the bottom line of each panel). P values were determined by the Mann-Whitney and Wilcoxon matched-pairs signed-rank tests. *, P < 0.05; **, P < 0.01; †, P < 0.001.