TABLE 1.
Inhibitory activities and helicity of conjugated peptides and control peptides
| Peptide | Mean IC50 ± SD (nM)a |
Secondary structure (with N46) |
|||
|---|---|---|---|---|---|
| HIV-1 IIIB (tier 1) | HIV-1 Bal (tier 1) | Cell-cell fusion | Helicity (%) | Tm (°C) | |
| WQ | 123.4 ± 6.5 | 126.2 ± 9.2 | 159.5 ± 9.5 | 83.8 | 65.1 |
| WQ-LDL | 3.7 ± 1.1 | 3.6 ± 0.2 | 6.4 ± 2.7 | 86.0 | 80.9 |
| WQ-IDI | 3.7 ± 0.3 | 3.2 ± 0.2 | 6.4 ± 1.8 | 85.2 | 81.9 |
| WQ-LDI | 3.6 ± 0.2 | 3.1 ± 0.1 | 7.2 ± 1.0 | 84.2 | 80.5 |
| WQ-IDL | 1.6 ± 0.1 | 2.5 ± 0.1 | 5.6 ± 1.2 | 85.1 | 81.8 |
| MT-WQ-IDL | 0.6 ± 0.1 | 0.6 ± 0.1 | 1.2 ± 0.2 | 90.8 | 90.7 |
| MT-WQ | 8.8 ± 0.4 | 6.7 ± 0.5 | 14.8 ± 2.8 | 84.4 | 74.8 |
| T20 | 71.8 ± 2.2 | 70.5 ± 0.9 | 91.0 ± 1.2 | NAb | NA |
| C34 | 7.2 ± 0.2 | 7.6 ± 0.2 | 18.8 ± 1.6 | 85.0 | 67.9 |
a
IC50 data were derived from the results of three independent experiments.
b
NA, not applicable.