TABLE 1.

Representative MERS-CoV strains isolated in the 2012-2015 outbreaks and their mutations in MERS-CoV RBD containing residues 377 to 588^a

GenBank protein ID	Yr isolated	Host	Region	Mutation in MERS-CoV RBD residue:																No. of mutations
				400	424	431	434	457	460	482	506	509	510	520	522	529	530	534	582
AFS88936.1	2012	Human	EMC	K	T	A	A	S	S	A	L	D	D	A	Q	I	V	V	N	0
AFY13307.1	2012	Human	England								F									1
AGG22542.1	2012	Human	England								F									1
AGV08379.1	2012	Human	KSA									G								1
AGV08584.1	2012	Human	KSA															A		1
AHI48528.1	2013	Human	KSA			P				V										2
AHI48733.1	2013	Human	KSA				V													1
AHC74088.1	2013	Human	Qatar						F											1
AGV08438.1	2013	Human	KSA																I	1
AID55090.1	2014	Human	KSA		I															1
AID55095.1	2014	Human	KSA		I															1
AID55087.1	2014	Human	KSA												H					1
AKL59401.1	2015	Human	Korea														L			1
ALB08322.1	2015	Human	Korea										G							1
ALB08289.1	2015	Human	Korea													T				1
AHY22545.1	2013	Camel	KSA	N																1
AHL18090.1	2013	Camel	Egypt				S													1
AHX00711.1	2013	Camel	KSA					G												1
AHX00721.1	2013	Camel	KSA					G												1
AHY22555.1	2013	Camel	KSA											S						1

^aEMC, Erasmus Medical Center; KSA, Saudi Arabia. Key residues in the RBM of the RBD are in bold.