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. 2016 Dec 19;7:2018. doi: 10.3389/fmicb.2016.02018

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Copyright © 2016 Vestergaard, Leng, Haaber, Bojer, Vegge and Ingmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene inactivations affecting susceptibility to antimicrobial agents to one or more of the eight antimicrobial agents tested. The effect on susceptibility is displayed using a gray scale indicating fold reductions in sensitivity: , and . The genes are divided into the categories: (1) Membrane transporters, (2) Metabolism, (3) Replication and DNA repair, (4) Pro-phage encoded genes, (5) Protein synthesis, (6) Transcriptional regulators, chaperones, cell wall and membrane stress mechanisms and (7) Unassigned and hypothetical genes. CIP (Ciprofloxacin), OXA (Oxacillin), LZD (Linezolid), FOF (Fosfomycin), DAP (Daptomycin), MUP (Mupirocin), VAN (Vancomycin) and GEN (Gentamicin).

Inline graphic — Gene inactivations affecting susceptibility to antimicrobial agents to one or more of the eight antimicrobial agents tested. The effect on susceptibility is displayed using a gray scale indicating fold reductions in sensitivity: , and . The genes are divided into the categories: (1) Membrane transporters, (2) Metabolism, (3) Replication and DNA repair, (4) Pro-phage encoded genes, (5) Protein synthesis, (6) Transcriptional regulators, chaperones, cell wall and membrane stress mechanisms and (7) Unassigned and hypothetical genes. CIP (Ciprofloxacin), OXA (Oxacillin), LZD (Linezolid), FOF (Fosfomycin), DAP (Daptomycin), MUP (Mupirocin), VAN (Vancomycin) and GEN (Gentamicin).