Table 1.

Antimicrobial agents used in the screening for intrinsic resistance determinants, as well as the primary target and process affected by the respective agents.

Antimicrobial	Primary target	Process affected	JE2 MIC (μg/ml)
Ciprofloxacin	DNA gyrase	DNA replication	32
Oxacillin	Transpeptidase	Cell wall synthesis	0.5
Linezolid	50S rRNA subunit	Protein synthesis	3
Fosfomycin	MurA	Cell wall synthesis	0.75
Daptomycin	Cytoplasmic membrane	Membrane permeability	0.19
Mupirocin	Isoleucyl t-RNA	Protein synthesis	0.125
Vancomycin	NAM/NAG peptides	Cell wall synthesis	1.5
Gentamicin	30S rRNA subunit	Protein synthesis	1.5

The MIC (μg/ml) of wild type strain JE2 is displayed for each agent.