Table 2. List of genes that participate in two or more fusion events.
| No. | Gene | Known status* | Cases† | 5′‡ | 3′‡ | Chromosomal band | Title |
|---|---|---|---|---|---|---|---|
| 1 | MLL | Known | 12 | 10 | 2 | 11q23.3 | Myeloid/lymphoid or mixed-lineage leukemia |
| 2 | CREBBP | Known | 4 | 2 | 2 | 16p13.3 | CREB-binding protein |
| 3 | RUNX1 | Known | 4 | 4 | 0 | 21q22.12 | Runt-related transcription factor |
| 4 | ALK | Known | 3 | 0 | 3 | 2p23.2 | Anaplastic lymphoma kinase |
| 5 | MLLT2 | Known | 3 | 2 | 1 | 4q21.3 | Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 2 |
| 6 | NPM1 | Known | 3 | 2 | 1 | 5q35.1 | Nucleophosmin |
| 7 | RET | Known | 3 | 0 | 3 | 10q11.21 | Ret protooncogene |
| 8 | FUS | Known | 3 | 2 | 1 | 16p11.2 | Fusion [involved in t(12;16) in malignant liposarcoma] |
| 9 | BCR | Known | 3 | 2 | 1 | 22q11.23 | Breakpoint cluster region |
| 10 | EWSR1 | Known | 3 | 3 | 0 | 22q12.2 | Ewing sarcoma breakpoint region 1 |
| 11 | RBM15 | Known | 2 | 1 | 1 | 1p13.3 | RNA-binding motif protein 15 |
| 12 | NTRK1 | Known | 2 | 0 | 2 | 1q23.1 | Neurotrophic tyrosine kinase, receptor, type 1 |
| 13 | RPS6KC1 | New | 2 | 0 | 2 | 1q32.3 | Ribosomal protein S6 kinase, 52 kDa, polypeptide 1 |
| 14 | TFG | Known | 2 | 2 | 0 | 3q12.2 | TRK-fused gene |
| 15 | KIAA0372 | New | 2 | 1 | 1 | 5q15 | KIAA0372 |
| 16 | HINT1 | New | 2 | 0 | 2 | 5q23.3 | Histidine triad nucleotide-binding protein 1 |
| 17 | TGFBI | New | 2 | 0 | 2 | 5q31.1 | Transforming growth factor, beta-induced, 68 kDa |
| 18 | CREB3L2 | Known | 2 | 2 | 0 | 7q33 | cAMP-responsive element binding protein 3-like 2 |
| 19 | FGFR1 | Known | 2 | 1 | 1 | 8p12 | Fibroblast growth factor receptor 1 |
| 20 | MYST3 | Known | 2 | 1 | 1 | 8p11.21 | MYST histone acetyltransferase 3 |
| 21 | NR4A3 | Known | 2 | 0 | 2 | 9q22.33 | Nuclear receptor subfamily 4, group A, member 3 |
| 22 | MLLT10 | Known | 2 | 1 | 1 | 10p12.31 | Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 |
| 23 | MYST4 | Known | 2 | 1 | 1 | 10q22.2 | MYST histone acetyltransferase 4 |
| 24 | NUP98 | Known | 2 | 2 | 0 | 11p15.4 | Nucleoporin 98 kDa |
| 25 | PICALM | Known | 2 | 0 | 2 | 11q14.2 | Phosphatidylinositol-binding clathrin assembly protein |
| 26 | MARS | New | 2 | 0 | 2 | 12q13.3 | Methionine-tRNA synthetase |
| 27 | CPM | New | 2 | 0 | 2 | 12q15 | Carboxypeptidase M |
| 28 | RARA | Known | 2 | 0 | 2 | 17q21.2 | Retinoic acid receptor, alpha |
| 29 | NBR2 | New | 2 | 2 | 0 | 17q21.31 | Neighbor of BRCA1 gene 2 |
| 30 | Hs.410998 | New | 2 | 0 | 2 | 17q23.2 | Strong similarity to protein ref:NP_006631.1 MLL septin-like fusion; septin D1 |
| 31 | OAZ1 | New | 2 | 2 | 0 | 19p13.3 | Ornithine decarboxylase antizyme 1 |
| 32 | FKBP8 | New | 2 | 0 | 2 | 19p13.11 | FK506-binding protein 8, 38 kDa |
| 33 | Hs. 102754 | New | 2 | 1 | 1 | 21q21.1 | cDNA FLJ38295 full insert sequence, clone FCBBF3012332 |
| 34 | MKL1 | Known | 2 | 1 | 1 | 22q13.1 | Megakaryoblastic leukemia 1 |
| 35 | TUBGCP6 | New | 2 | 0 | 2 | 22q13.33 | Tubulin, gamma complex-associated protein 6 |
| 36 | SHANK3 | New | 2 | 2 | 0 | 22q13.33 | SH3 and multiple ankyrin repeat domains 3 |
*
The genes listed in the Cancer Genome Anatomy Project Recurrent Chromosome Aberrations in Cancer Database and/or in the list of Futreal et al. (2) are considered to be known as a recurrent fusion gene.
†
Total number of cases in which the gene participates.
‡
Number of cases where the gene participates as the 5′ partner (5′) or the 3′ partner (3′).