Table 1. Characteristics of 6-month-old males having the four combinations of wild-type and mutant Ins2 and Bdkrb2 genes.

Genotype	Bdkrb2+/+Ins2+/+	Bdkrb2−/−Ins2+/+	Bdkrb2+/+Ins2+/C96Y	Bdkrb2−/−Ins2+/C96Y
Number	4	4	9	7
BW, g	36.8 ± 1.2	34.2 ± 3.5	24.7 ± 2.0†	24.6 ± 1.4†
HW, mg	203 ± 16	200 ± 31	150 ± 11*	157 ± 12*
HW/BW, mg/g	5.5 ± 0.5	5.9 ± 0.6	6.3 ± 0.6	6.4 ± 0.4
KW, mg	212 ± 7	237 ± 19	274 ± 21	330 ± 18†‡
KW/BW, mg/g	5.8 ± 0.3	6.9 ± 1.9	11.4 ± 0.9†	13.5 ± 0.5†‡
Blood pressure, mmHg (1 mmHg = 133 Pa)	118 ± 3	124 ± 5	123 ± 3	126 ± 4
Hematocrit, %	42.8 ± 2.1	44.0 ± 0.5	45.9 ± 1.8	46.2 ± 1.6
Plasma glucose, mmol/liter	10.9 ± 1.3	8.2 ± 1.4	38.8 ± 1.9†	37.9 ± 1.4†
Food intake, g/day	3.5 ± 0.3	3.9 ± 0.8	12.2 ± 1.5*	14.0 ± 2.6*
Urine volume, ml/day	1.3 ± 0.1	1.2 ± 0.1	26.1 ± 4.6*	33.0 ± 6.7*
Urinary albumin, g/day	7.6 ± 2.0	11.0 ± 3.0	54 ± 12*	209 ± 40†§

Data are given as mean ± SEM. BW, body weight; HW, heart weight; KW, kidney weight.

^*P < 0.05.

^†P < 0.001 vs. wild type.

^‡P < 0.05.

^§P < 0.001 vs Bdkrb2^+/+ Ins2^+/C96Y.