Table 2. The amount of mRNA in the kidney of the four groups of animals.

Genotype	Bdkrb2+/+Ins2+/+	Bdkrb2−/−Ins2+/+	Bdkrb2+/+Ins2+/C96Y	Bdkrb2−/−Ins2+/C96Y
B2 receptor	32.8 ± 4.3 (100 ± 13)	0.0 ± 0.0* (0 ± 0)	67.7 ± 12.7* (207 ± 39)	0.0 ± 0.0*† (0 ± 0)
B1 receptor	3.1 ± 0.4 (100 ± 13)	35.2 ± 3.4* (1,132 ± 109)	37.1 ± 2.1* (1,196 ± 67)	78.0 ± 8.0*† (2,511 ± 257)
Megsin	0.257 ± 0.034 (100 ± 13)	0.306 ± 0.040 (119 ± 16)	0.462 ± 0.049* (180 ± 19)	0.831 ± 0.105*† (323 ± 41)
Nephrin	1.44 ± 0.19 (100 ± 13)	1.61 ± 0.16 (112 ± 11)	3.03 ± 0.39* (210 ± 27)	4.47 ± 0.28*† (310 ± 19)

Data are given as pg mRNA of genes of interest in μg total RNA (mean ± SEM). Relative expression levels (% wild type) are shown in parentheses.

^*P < 0.05 vs. wild type.

^†P < 0.05 vs. Bdkrb2^+/+ Ins2^+/C96Y.