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Deletion mutations in exon 19 of EGFR from NSCLCs sensitive to TKIs, gefitinib (G) or erlotinib (E); all lack four amino acids, LREA, which are conserved among vertebrate species. (A) Nucleotide alignments. (B) Amino acid alignments. (C) Amino acid alignments of EGFR from various species. All alignments were generated by using Vector nti software. See Table 1 for characteristics of patients.
