Table 1. Probable orthologous correspondences of CD33-related Siglecs in the five mammalian species compared in this study.
| Human | Chimpanzee | Baboon | Mouse | Rat |
|---|---|---|---|---|
| CD33rSiglecs found within the Siglec gene cluster | ||||
| CD33/Siglec-3 | CD33/Siglec-3 | CD33/Siglec-3 | CD33/Siglec-3 | CD33/Siglec-3 |
| Siglec-5 | *Siglec-V | Siglec-5 | Siglec-F | Siglec-F |
| Siglec-6 | Siglec-6 | *Siglec-VI | ||
| Siglec-7 | Siglec-7 | NF | NF | NF |
| Siglec-8 | Siglec-8 | Siglec-8 | NF | NF |
| Siglec-9 | Siglec-9 | Siglec-9 | Siglec-E | Siglec-E |
| Siglec-10 | Siglec-10 | Siglec-10 | Siglec-G | Siglec-G |
| *Siglec-XII | Siglec-12 | NF | NF | NF |
| NF | Siglec-13 | Siglec-13 | NF | NF |
| CD33rSiglecs found outside of the Siglec gene cluster | ||||
| Siglec-11 | Siglec-11 | ? | NF | NF |
| NF | NF | ? | Siglec-H | *Siglec-H |
These data are based on the current paper, our unpublished observations, past literature, and other genomic information available on-line to date (including chimpanzee and rat high-throughout genomic sequences in the GenBank database). Criteria used to assign orthologs include sequence similarity, map location, gene structure, and phylogenetic relationships. NF, the corresponding Siglec was not found in available data in this species; *, Siglec-like molecules missing the arginine residue required for optimal Sia recognition; ?, published genomic information to date is not sufficient to determine status.