Fig. 3.

Targets sites are short GT-rich sequences. (a) The number of telomere additions in 50-bp windows (black bars above chromosome) between CAN1 and PCM1 compared to the number of four-base sequences made up of two adjacent TG, GT, or GG dinucleotides (e.g., four contiguous bases, gray bars below the chromosome). (b) The number of telomere additions at sequences containing solely G/T (gray) or A/C (black) nucleotides as a function of sequence length. The length includes bases that would be truncated if the breakpoint fell in the middle of the runs of G/T or A/C nucleotides. Despite the preference for G/T-rich stretches, the numbers of different G/T-rich and A/C-rich stretches between CAN1 and PCM1 are roughly identical and are close to distributions that would be predicted by random distribution (data not shown).