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Inhibition of the HIF signaling pathway by chetomin alters the survival of EndoC-βH3 PIs at hypoxia. (a) Morphological images of EndoC-βH3 PIs after a 6-day chetomin treatment. Scale bars: 200 μm. (b) Expression of HIF1α target genes in chetomin-treated EndoC-βH3 PIs cultured under hypoxia versus control PIs was analyzed by qPCR. Each point represents the mean ± SEM of two independent experiments performed in duplicates. *p < 0.05, **p < 0.01. DMSO, dimethyl sulfoxide.
