Table 1.

Rodent models organized by group and characterized by genetic construction, expression level of LRRK2 protein, and the presence, +, or absence, —, of neurodegeneration and/or behavioral phenotypes.

	REFERENCE	GENETIC CONSTRUCT	LRRK2 PROTEIN EPXRESSION LEVEL	PHENOTYPE
				NEURODEGENERATION	MOTOR ACTIVITY
MOUSE MODELS	Li 2010	BAC LRRK2 WT	x 6	—	↑↑
		BAC LRRK2 G2019S	x 6	—	—
	Herzig 2011	Lrrk2 KO	—	—	—
		Lrrk2 KI G2019S❖	x 1	—	—
	Longo 2014	Lrrk2 KI G2019S❖	x 1	—	↑↑
	Melrose 2010	BAC LRRK2 WT	x 3.5	—	— (with increased thigmotaxis)
		BAC LRRK2 G2019S■	x 2.5	—	—
	Winner 2010	BAC LRRK2 G2019S■	NR	NR	NR
	Lee 2010	HSV-LRRK2 G2019S	NR	+++	NR
	Lin 2009	tetO-LRRK2 G2019S/CamKII-tTA	x 8-16	—	↑↑
		Lrrk2 KO	—	—	—
	Chen 2012	CMVE-PDGFβ-LRRK2 G2019S	NR	+++	↓↓ (+)
	Ramonet 2011	CMVE-PDGFβ-LRRK2 G2019S	x 3-5	+	—
		CMVE-PDGFβ-LRRK2 R1441C	x 3-5	—	↓
	Li 2009	BAC LRRK2 R1441G′	x 5-10	—	↓↓↓ (+)
	Bichler 2013	BAC LRRK2 R1441G′	NR	NR	↓
	Dranka 2013	BAC LRRK2 R1441G′	NR	—	↓
	Dranka 2014	BAC LRRK2 R1441G′	NR	NR	↓
	Tong 2009	Lrrk2 KI R1441C	x 1	—	—
	Maekawa 2012	CMV-LRRK2 I2020T	x 1.3	—	↓↑
	Andres-Mateos 2009	Lrrk2 KO	—	—	—
	Tong 2010	Lrrk2 KO*	—	—	NR
	Tong 2012	Lrrk2 KO*	—	NR	NR
	Hinkle 2012	Lrrk2 KO	—	—	↑ (with increased thigmotaxis)
RAT MODELS	Ness 2013	Lrrk2 KO†	—	NR	NR
	Baptista 2013	Lrrk2 KO†	—	NR	NR
	Dusonchet 2011	rAd-LRRK2 WT	x 2	—	NR
		rAd-LRRK2 G2019S	x 2	+	NR
	Zhou 2011	tTA-LRRK2 G2019S; constitutive expression	NR	—	—
		tTA-LRRK2 G2019S; temporal expression	NR	—	↑
	Lee 2015	BAC LRRK2 G2019S	x 5-8	—	↓↑
	Daher 2014	Lrrk2 KO +rAAv α-synuclein	—	—	NR
		wild-type +rAAv α-synuclein	x 1	+	NR
	Daher 2015	wild-type +rAAv α-synuclein	x 1	+	NR
		BAC LRRK2 G2019S +rAAv α-synuclein	x 20-30	++	NR

Superscript symbols (❖, ■, ○, * and †) are used to denote rodents from the same line. Neurodegeneration is defined here as loss of TH+ cells. Up or down arrows are used to indicate an observed increase or decrease, respectively, in motor activity. (+) = phenotype reversed by administration of L-DOPA. NR = not reported.