Fig. 4.
Expression of immature neuronal marker proteins in DG-SGZ and SVZ of WT and PDGF-APPSw,Ind transgenic (Tg) mice. Sections through DG (A and B) and SVZ (C and D) of 3-month-old (A and C) and 1-year-old (B and D)WTand PDGF-APPSw,Ind transgenic mice were stained with an antibody against DCX (brown). Note that the number of DCX-immunoreactive cells in B (like the number of BrdUrd-labeled cells in Fig. 2D) was close to 0. Double-label immunohistochemistry with antibodies against BrdUrd and DCX (E) or BrdUrd and Neuro D (F) was performed on sections from 3-month-old transgenic mice and showed expression of DCX and Neuro D in BrdUrd-labeled cells in both DG-SGZ and SVZ.