TABLE 2.

Functional categories of genes with 1.7-fold more expression in the M. tuberculosis sigD mutant strain than in strain H37Rv

Gene family and name	Fold change	FDR	Product, its function, and additional comments
Adaptation
Rv3811	1.7	0.001	Cold shock protein
Rv3648	1.8	0.004	Cold shock protein A
Rv3268	1.9	<0.001	Seems to be coregulated with CSPA-related protein Rv3267 (ratio = 1.5, FDR = 0.002)
Rv3269	1.9	<0.001	Heat shock protein, chaperonin, seems to be coregulated with Rv3267 and RV3268
Lipid metabolism
Rv1094	2.4	<0.001	DesA2, Acyl-[ACP]-desaturase
Rv3229	4.4	<0.001	DesA3, linolenoil CoA desaturase
Cell wall process
MT1416	2.0	0.001	Desaturase-related protein
Rv1614	2.2	<0.001	Lgt, prolipoprotein diacylglyceryl transferase
Rv1312	1.7	0.001	Secreted protein
Rv3920c	2.3	<0.001	Jag-like protein, involved in cell division
Regulatory
Rv0823c	2.5	<0.001	Transcriptional regulatory protein
Rv1297	2.2	<0.001	Rho, transcription termination factor, Rho homologue
Rv0704	1.8	0.002	RplB, 50S ribosomal protein, peptidyltransferase activity
Respiration
Rv3230c	1.9	<0.001	Oxidoreductase
Rv1644	2.1	<0.001	TsnR, 23S rRNA methyltransferase
Unknown
Rv0516c	1.8	0.036	Hypothetical protein
Rv2393	1.8	0.001	Hypothetical protein
Rv3212	2.1	<0.001	Hypothetical protein
Rv3376	1.9	<0.001	Hypothetical protein
Rv3647c	1.7	0.001	Hypothetical protein
PE-PGRS family
Rv0124	2.4	0.004	PE-PGRS 2
MT0132	2.3	0.02	PE-PGRS 2
Rv0834c	2.2	0.001	PE-PGRS 14
MT1123	2.1	0.001	PE-PGRS 22
Rv1396c	2.1	0.008	PE-PGRS 25
Rv1450c	1.9	<0.001	PE-PGRS 27
MT1499	1.8	0.002	PE-PGRS 28
Rv2490c	2.0	0.001	PE-PGRS 43
Rv3344c	2.1	<0.001	PE-PGRS 49
Rv3345c	2.2	<0.001	PE-PGRS 50
MT3612	1.9	<0.001	PE-PGRS 53
MT3615.3	2.7	0.021	PE-PGRS 57
MT3615.1	2.3	0.023	PE-PGRS
MT3448	2.1	0.001	PE-PGRS
MT3582	1.7	<0.001	PPE 19