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. 2004 Aug 5;23(17):3559–3569. doi: 10.1038/sj.emboj.7600351

Figure 4.

Figure 4

Cyclin T1 disrupts mitochondrial structure and function in mouse myocardium. (A) Abnormal mitochondrial ultrastructure in αMHC-cyclin T1 mice (right), compared with nontransgenic littermate controls (ntg; left). Bar, 0.5 μm. (B) Deficient mitochondrial enzyme activities in αMHC-cyclin T1 mice (filled bars), compared with nontransgenic littermates (open bars; N=8 for both genotypes). (C) MtDNA copy number in ventricular myocardium. DNA from nontransgenic and αMHC-cyclin T1 mice was used to amplify a 648 bp fragment of mtDNA (mt-Cox1) and a 316 bp fragment of genomic DNA (5S ribosomal RNA). Left lane, 100 bp ladder.