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. 2016 Aug 16;101(1):121–126. doi: 10.1189/jlb.3MR0316-115R

Figure 1. Potential mechanisms for STING-mediated regulation of TLR activation in myeloid-derived cells or tissue-resident sentinels.

Figure 1.

(A) A cell-intrinsic mechanism where STING activation not only initiates proinflammatory loops but also maintains critical levels of negative regulators that blunt TLR signaling within the same cell type. (B) A cell-extrinsic mechanism where STING-dependent signaling in one cell leads to the induction of both proinflammatory cytokines and tolerogenic cytokines like IDO-1. IDO-1 then recruits and activates T-regulatory cells (Tregs) that curb TLR-drive inflammation in other cells.