TABLE 1.
Cytosolic and endosomal DNA sensors contribute to disease manifestations of DNaseII−/− IFNaR−/− mice
| Targeted genes | Abbreviation | Arthritis | ANA | Splenomegaly |
|---|---|---|---|---|
| IFNaR−/− DNaseII+/− | Het | − | − | − |
| IFNaR−/− DNaseII−/− | DKO | ++++ | ++++ | ++++ |
| IFNaR−/− DNaseII−/− STING−/− | STING TKO | − | ++++ | +++ |
| IFNaR−/− DNaseII−/− AIM2−/− | AIM2 TKO | ++ | ++++ | ++ |
| IFNaR−/− DNaseII−/− Unc93b13d/3d | Unc93b1 TKO | +++ | − | + |
Relative severity of clinical manifestations is indicated as a scale from the Het phenotype (−) to the DKO phenotype (++++).