TABLE 2.
Donor | Recipient | Arthritis | ANA | Splenomegaly |
---|---|---|---|---|
Het | Het | − | − | − |
Het | DKO | − | ++ | − |
DKO | Het | − | + | − |
DKO | DKO | ++++ | ++++ | ++++ |
DKO | Unc93b1 TKO | +++ | ++++ | ++++ |
Unc93b1 TKO | DKO | +++ | − | + |
Unc93b1 TKO | Unc93b1 TKO | ++ | − | + |
Relative severity of clinical manifestations is indicated as a scale from the Het phenotype (−) to the DKO phenotype (++++).