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. 2016 Nov 26;12(12):1533–1543. doi: 10.7150/ijbs.15943

Figure 5.

Figure 5

COX-2 in TAMs regulates p-Akt, MMP-9 and EMT in vivo. The animal model was constructed by injecting 4T1 cells alone or with RAW264.7-derived TAMs transfected with adenoviral COX-2 or siRNA COX-2 into the mammary fat pads of NOD/SCID mice. p-Akt, MMP-9, E-cadherin and Vimentin in the tumor tissues were evaluated by IHC (original magnification, ×400). The number of stained and unstained cells was counted to generate the percentage of positive cells in each group. All the data were presented as the mean ± SD, n = 10, *p < 0.05 and **p < 0.01.