Figure 4.

Effects of MHY2256 or salermide on cell cycle regulation. MCF-7 (A) and SKOV-3 (B) cells were treated with the indicated concentrations for 48 h. Cells stained with propidium iodide (PI) were subjected to flow cytometric analysis to determine the cell distributions in each phase of the cell cycle. Statistical analysis was performed using one-way analysis of the variance (ANOVA) followed by Bonferroni's multiple comparison tests. *p<0.05 indicate significant differences between control and treatment groups.