Table 1.
Selected lifespan extending interventions and glucose response
| Organism | Intervention | Glucose Level** | |
| Diet§ | Genetic | ||
| Yeast | GR | ▾ [189, 190] | |
| Worms | GR | ▾ [191] | |
| Mice/Rats | DR | ▾ [192, 193] | |
| MR | ▾ [194, 195] | ||
| ADF | ▾ [196, 197] | ||
| Ames dwarf | ▾ [198] | ||
| Snell dwarf | ▾ [199, 200] | ||
| GHR mutant | ▾ [201] | ||
| FIRKO | ▾ [120, 202] | ||
| AC5 – KO | ▾ [203–205] | ||
| Atg5 OE | ▾ [206] | ||
| Fgf21 OE | ▾ [207] | ||
| αMUPA OE | ▾ [208] | ||
| S6K1 KO | ▾ [209] | ||
| RIIβ KO | ▾ [210] | ||
§GR = glucose restriction, MR = methionine restriction, DR = dietary restriction, ADF = alternate day fasting. **Represents either decreased glucose level or increased glucose tolerance/clearance.