Table 1.

Multivariate association analysis of immunomodulatory germline variants with melanoma recurrence-free survival

SNP	Gene	Position	Genotype (%)	Counts	HR (CI 95%)	p Value*
			GG (0.6)	611	Ref
rs1562302	IL36B	chr2:113810458	GA (0.36)	363	0.70 (0.51 to 95)
			AA (0.04)	43	0.48 (0.17 to 1.30)	0.026
			AA (0.52)	527	Ref
rs2221903	IL21	chr4:123538912	AG (0.39)	394	1.19 (0.90 to 1.58)
			GG (0.09)	100	0.52 (0.28 to 0.97)	0.016
			CC (0.46)	471	Ref
rs2069840	IL6	chr7:22768572	CG (0.45)	456	0.59 (0.44 to 0.79)
			GG (0.09)	93	0.77 (0.48 to 1.22)	0.0022
			TT (0.24)	247	Ref
rs6783	IL17D	chr13:21297050	TC (0.52)	522	0.64 (0.46 to 0.90)
			CC (0.24)	241	0.63 (0.42 to 0.95)	0.024
			CC (0.51)	519	Ref
rs7145531	IL25	chr14:23842017	CT (0.42)	426	1.39 (1.05 to 1.86)
			TT (0.07)	76	0.55 (0.28 to 1.08)	0.0035
			CC (0.46)	466	Ref
rs3811178	IL25	chr14:23845244	CT (0.44)	452	1.30 (0.98 to 1.74)
			TT (0.10)	100	0.70 (0.41 to 1.21)	0.028
			AA (0.41)	414	Ref
rs2292980	IRF8	chr16:85945076	AG (0.48)	490	0.68 (0.51 to 0.91)
			GG (0.11)	114	0.82 (0.51 to 1.33)	0.038
			AA (0.52)	522	Ref
rs12926854	IRF8	chr16:85951258	AG (0.41)	413	0.67 (0.50 to 0.90)
			GG (0.07)	72	0.98 (0.59 to 1.61)	0.022

The results of multivariate analysis showing the most significant associations (p<0.05) between 72 tagging SNPs in 44 immunomodulatory genes and melanoma recurrence-free survival in 1022 melanoma patients ascertained at NYU Medical Center. The associations, HRs and 95% CIs were calculated using Cox regression models under two degrees of freedom test, adjusted by age at diagnosis, gender, stage, thickness, ulceration and histological subtype.

Of note, none of the associations with RFS reached Bonferroni level of significance (p<0.0007).

^*p Values were determined using two degrees of freedom test.

SNP, single nucleotide polymorphism.