Table 3.

The associations of genetic variants from fine mapping analysis in 1q32.1 with melanoma overall survival

					Conditioned by rs3024493 genotype
SNP	Position	Genotype	HR (95% CI)	p Value	HR (95% CI)	p Value
		GG	Ref		Ref
rs3024493	chr1:206943968	GT	0.58 (0.39 to 0.86)		–
		TT	4.73 (1.68 to 13.29)	0.00069	–	1
		GG	Ref		Ref
rs3024491	chr1:206945046	GT	0.56 (0.37 to 0.87)		0.75 (0.42 to 1.06)
		TT	0.47 (0.27 to 0.82)	0.0086	0.54 (0.28 to 1.07)	0.13
		CC	Ref		Ref
rs2222202	chr1:206945381	CT	0.58 (0.40 to 0.84)		0.59 (0.36 to 0.97)
		TT	0.50 (0.31 to 0.81)	0.0042	0.41 (0.20 to 0.86)	0.03
		AA	Ref		Ref
rs1800896	chr1:206946897	AG	0.54 (0.35 to 0.83)		0.64 (0.40 to 1.02)
		GG	0.49 (0.29 to 0.83)	0.0067	0.56 (0.29 to 1.08)	0.11
		TT	Ref		Ref
rs1800890	chr1:206949365	TA	0.49 (0.32 to 0.74)		0.57 (0.34 to 0.96)
		AA	0.46 (0.24 to 0.88)	0.00082	0.38 (0.16 to 0.92)	0.028
		CC	Ref		Ref
rs1028182	chr1:207001879	CT	1.66 (1.11 to 2.48)		1.61 (1.07 to 2.43)
		TT	0.74 (0.31 to 1.78)	0.022	0.57 (0.23 to 1.42)	0.012
		AA	Ref		Ref
rs960326	chr1:207014776	AG	2.19 (1.39 to 3.45)		2.13 (1.34 to 3.37)
		GG	2.90 (0.67 to 12.57)	0.0032	3.04 (0.69 to 13.4)	0.0048
		CC	Ref		Ref
rs1400986	chr1:207038686	CT	1.52 (1.07 to 2.15)		1.80 (1.16 to 2.79)
		TT	0.71 (0.22 to 2.29)	0.041	0.44 (0.059 to 3.30)	0.016

The results of association analysis of 24 SNPs selected for fine mapping of 1q32.1 associations with melanoma overall survival in 1022 melanoma patients ascertained at NYU Medical Center. The associations, HRs and 95% CIs were calculated using Cox regression models under two degrees of freedom test, adjusted by age at diagnosis, gender, stage, thickness, ulceration and histological subtype. Last columns show the association results conditioned on genotypes of rs3024493.

p Values were determined using two degrees of freedom test.

SNP, single nucleotide polymorphism.