Table 1.
Correlation between the clinicopathological variables and ALP or LDH in triple negative breast cancer cases.
| Variables | Cases (n=253) | ALP | LDH | ||||
|---|---|---|---|---|---|---|---|
| Low No. (%) |
High No. (%) |
P value | Low No. (%) |
High No. (%) |
P value | ||
| Age (years) | <0.001* | <0.001* | |||||
| ≤50 | 166 | 131(78.9%) | 35(21.1%) | 93(56.0%) | 73(44.0%) | ||
| >50 | 87 | 46(52.9%) | 41(47.1%) | 28(32.2%) | 59(67.8%) | ||
| menopause | <0.001* | <0.001* | |||||
| no | 103 | 54(52.4%) | 49(47.6%) | 34(33.0%) | 69(67.0%) | ||
| yes | 150 | 123(82.0%) | 27(18.0%) | 87(58.0%) | 63(42.0%) | ||
| BMI | 0.096 | 0.007* | |||||
| ≤25 | 194 | 141(72.7%) | 53(27.3%) | 102(52.6%) | 92(47.4%) | ||
| >25 | 59 | 36(61.0%) | 23(39.0%) | 19(32.2%) | 40(67.8%) | ||
| Tumor size | 0.632 | 0.120 | |||||
| ≤2.0cm | 82 | 59(72.0%) | 23(28.0%) | 45(54.9%) | 37(45.1%) | ||
| >2.0cm | 171 | 118(69.0%) | 53(31.0%) | 76(44.4%) | 95(55.6%) | ||
| Tumor status | 0.522 | 0.020* | |||||
| T1 | 72 | 53(73.6%) | 19(26.4%) | 45(62.5%) | 27(37.5%) | ||
| T2 | 141 | 97(68.8%) | 44(31.2%) | 60(42.6%) | 81(57.4%) | ||
| T3 | 21 | 16(76.2%) | 5(23.8%) | 10(47.6%) | 11(52.4%) | ||
| T4 | 19 | 11(57.9%) | 8(42.1%) | 6(31.6%) | 13(68.4%) | ||
| TNM staging | 0.063 a | 0.057 a | |||||
| I | 51 | 41(80.4%) | 10(19.6%) | 33(64.7%) | 18(35.3%) | ||
| II | 127 | 91(71.7%) | 36(28.3%) | 56(44.1%) | 71(55.9%) | ||
| III | 67 | 39(58.2%) | 28(41.8%) | 29(43.3%) | 38(56.7%) | ||
| IV | 8 | 6(75.0%) | 2(25.0%) | 3(37.5%) | 5(62.5%) | ||
| LN infiltrated | 0.001* | 0.001* | |||||
| No | 131 | 104(79.4%) | 27(20.6%) | 73(55.7%) | 58(44.3%) | ||
| Yes | 122 | 73(59.8%) | 49(40.2%) | 48(39.3%) | 74(60.7%) | ||
| Histological grade | 0.154 a | 0.073 a | |||||
| G1 | 3 | 3(100.0%) | 0(0.0%) | 0(0.0%) | 3(100.0%) | ||
| G2 | 124 | 92(74.2%) | 32(25.8%) | 66(53.2%) | 58(46.8%) | ||
| G3 | 126 | 82(65.1%) | 44(34.9%) | 55(43.7%) | 71(56.3%) | ||
| Chemotherapy | 0.244 | 0.116 | |||||
| no | 22 | 13(59.1%) | 9(40.9%) | 7(31.8%) | 15(68.2%) | ||
| yes | 231 | 164(71.0%) | 67(29.0%) | 114(49.4%) | 117(50.6%) | ||
| Radiotherapy | 0.941 | 0.504 | |||||
| no | 199 | 139(69.8%) | 60(30.2%) | 93(46.7%) | 106(53.3%) | ||
| yes | 54 | 38(70.4%) | 16(29.6%) | 28(51.9%) | 26(48.1%) | ||
Abbreviation: ALP alkaline phosphatase, LDH lactate dehydrogenase, BMI body mass index, LN lymph node.
a. Using Fisher's exact test
* P < 0.05, statistically significant.