Fig. 6. Light-induced cytotoxic response for 19 (A) and 26 (B) in MC28 cells, showing PDT (without saporin) and PCI (with saporin) effects. Cells were incubated with photosensitiser (50 nM) with or without saporin (20 nM) for 18 h. Irradiation was carried out for 3 and 5 min with a blue lamp. MTT assay was carried 72 h after irradiation. The experiments were repeated 3 times, and representative data are shown. Error bars = SD. Statistically significant difference between PCIconjugate19-saporin versus PDTconjugate19 (p < 0.0001) is indicated by ***. Likewise, statistically significant difference between PCIconjugate26-saporin versus PDTconjugate26 (p < 0.0001) is indicated by ***.
