Table 1. Physical and biochemistry characteristics in each group.
| NC | DN | DV | DL | DLV | |
|---|---|---|---|---|---|
| BW (g) | 368.67±9.74 | 283.14±14.87 | 330.33±6.74 | 314.34±30.03 | 298.67±1.76 |
| KW (g) | 1.12±0.09 | 1.62±0.17a | 1.05±0.08 | 1.60±0.06 | 1.54±0.03 |
| KW/BW (×10-3) | 3.02±0.16 | 5.78±0.61bb | 3.19±0.27 | 5.22±0.63a | 5.17±0.12a |
| SBP (mmHg) | 152.60±3.46 | 151.50±4.16 | 157.70±3.28 | 160.30±1.45 | 155.80±3.79 |
| DBP (mmHg) | 83.40±2.65 | 89.20±1.76 | 77.00±3.79 | 85.60±4.10 | 79.50±4.18 |
| FPG (mmol/L) | 6.40±0.24 | 21.59±5.72 | 19.05±2.76 | a24.24±2.67 | 23.67±6.03 |
| TG (mmol/L) | 0.45±0.06 | 1.73±0.10a | 0.49±0.13c | 1.76±0.24bb | 1.80±0.12bb |
| TC (mmol/L) | 2.40±0.11 | 2.51±0.23 | 2.31±0.16c | 2.56±0.20 | 2.38±0.25 |
| SA (g/L) | 28.02±1.64 | 24.90±2.87 | 29.09±1.48 | 23.17±2.84 | 24.69±1.38 |
| Ca (mmol/L) | 2.73±0.19 | 2.68±0.26 | 2.76±0.25 | 1.72±0.07 | 1.68±0.12 |
| PTH ng/L | 2.73±.012 | 3.22±0.15 | 3.02±0.14 | 6.02±0.24a c | 5.79±0.65a c |
| 25(OH)D (nmol/L) | 23.47±0.73 | 21.50±0.62bb | 23.71±0.32c | 25.15±0.53b | 24.43±0.81b |
NC, control group; DN, diabetic nephropathy group; DV, DN+1,25(OH)2D3 group; DL, DN+ lenti-shVDR group; DLV, DN+lenti-shVDR+1,25(OH)2D3 group; BW, body weight; KW, kidney weight; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TG, triglyceride; TC, total cholesterol; SA, serum albumin; Ca, serum calcium; PTH, serum parathyroid hormone.
a
P < 0.05 vs. NC group;
b
P < 0.05 vs. DV group;
c
P < 0.05 vs. DN group.