Table 1.
Demographic data between groups and in overall sample (ALL‐HD)
| Mean ± SD | |||
|---|---|---|---|
| Pre‐HD (n = 12) | Symp‐HD (n = 7) | ALL‐HD (n = 19) | |
| Demographics | |||
| Gender (M:F) | 7:5 | 5:2 | 12:7 |
| Age | 42.16 ± 12.14 (24, 64) | 51.57 ± 8.56 (41, 65)* | 46.58 ± 12.25 |
| Education (years) | 11.83 ± 2.28 | 11.57 ± 2.63 | 11.73 ± 2.35 |
| CAG | 42.16 ± 2.72 | 42.57 ± 1.51 | 42.31 ± 2.31 |
| ICV | 1425.24 ± 170.82 | 1429.82 ± 120.14 | 1426 ± 150.50 |
| Time to scan | −40.33 ± 108.73 (−242, 105) | −276.28 ± 70.70 (−364, −174)* | −127.26 ± 150.22 (−364, 105) |
| Probability of diagnosis | 0.21 ± 0.23 | – | – |
| Illness duration | – | 1.42 ± 0.78 | – |
| DBS | 269.00 ± 104.42 | 408.92 ± 142.04** | 320.55 ± 134.90 |
| UHDRS | 0.33 ± 0.65 (0, 2) | 17.42 ± 8.32 (11, 33) | 6.63 ± 9.75 |
| IQ estimate | 112.90 ± 5.48 | 110.82 ± 7.00 | 112.13 ± 5.98 |
| BDI‐II | 6.75 ± 7.60 | 3.85 ± 3.57 | 5.68 ± 6.45 |
| Trails B | 73.96 ± 23.63 | 158.00 ± 94.01** | 104.92 ± 70.86 |
| Speeded tapping | 215.86 ± 12.65 | 335.53 ± 100.04** | 259.96 ± 83.37 |
| HVLT total recall | 24.91 ± 4.29 | 18.71 ± 9.12 | 22.63 ± 6.96 |
| HVLT delayed recall | 8.75 ± 1.91 | 7.28 ± 3.63 | 8.21 ± 23.25 |
| HVLT % retention | 87.45 ± 10.46 | 88.72 ± 37.67 | 87.92 ± 23.25 |
| HVLT recognition discrimination index | 10.25 ± 1.21 | 9.00 ± 2.70 | 9.79 ± 1.93 |
| Reaction time (CNV) | 820.17 ± 268.94 | 1272.94 ± 382.69* | 971.09 ± 371.63 |
| Volume (mm3) | |||
| Right putamen | 2692.88 ± 505.79 | 1673.83 ± 226.60** | 2317.44 ± 654.61 |
| Left putamen | 2682.02 ± 579.64 | 1703.18 ± 192.96** | 2321.40 ± 673.10 |
| Right caudate | 3265.68 ± 662.22 | 2180.11 ± 199.59** | 2865.74 ± 755.45 |
| Left caudate | 3208.72 ± 711.01 | 2115.84 ± 156.22** | 2806.08 ± 781.30 |
CAG, cytosine–adenine–guanine; ICV, intracranial volume. IQ (NART: National Adult Reading Test 2nd Edition). Time to scan computed in days from EEG baseline to MRI. Probability of onset in 5 years calculated from Langbehn et al. (2004). Disease Burden Score (CAG‐35.5) × age; UHDRS, motor subscale score, Unified Huntington's Disease Rating Scale (pre‐HD, UHDRS <5; symp‐HD, UHDRS ≥ 5); predicted Full Scale IQ converted from performance on the National Adult Reading Scale. Nonparametric Whitney–Mann U tests for differences between groups; *P < 0.05; **P < 0.01.