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Possible therapeutic interventions in pelvic ischemia.
| Drug/intervention | Mechanism of action | Clinical effect in OAB | Effect in animals |
|---|---|---|---|
| α1-AR blockers | Increase in blood flow | Documented (males) | Documented |
| PDE5 inhibitors | Unknown | Documented (males) | Documented |
| Free radical scavengers | Tissue protection? | ? | Documented |
| β3-AR agonists | Increase in blood flow? | Documented | Documented |
| Stem cells | Unknown | Unknown | Documented? |
AR, adrenoceptor; OAB, overactive bladder; PDE5, phosphodiesterase type 5.
