Table 2.

Suggested Diagnostic Criteria for Critical Illness Polyneuropathy and Critical Illness Myopathy.^a

CIP	CIM
Critically ill (sepsis and multi-organ failure)	Not required; typically exposed to variable combination of neuromuscular blocking agent and corticosteroids in the setting of sepsis and multi-organ failure
Limb weakness is present	Limb weakness is present
Difficulty in weaning from mechanical ventilatory support with the exclusion of cardiac and pulmonary causes	Difficulty in weaning from mechanical ventilatory support with the exclusion of cardiac and pulmonary causes
Electrophysiological evidence of Axonal sensorimotor neuropathy	Electrophysiological evidence of Preserved sensory response (>80% of lower limit of normal) Reduced motor responses (compound muscle action potential <80% lower limit of normal) Normal repetitive nerve simulation, and EMG with short-duration, low-amplitude motor unit potential with early full or normal recruitment of motor unit action potentials Muscle inexcitability with direct muscle stimulation
Other causes of acute neuropathy should be excluded, for example, porphyria, acute massive intoxications of heavy metals, and vasculitis	Muscle biopsy consistent with myopathy and myosin loss

Abbreviations: CIM, critical illness myopathy; CIP, critical illness polyneuromyopathy; EMG, electromyography.

^a Adapted from Bolton⁷ and Lacomis et al.⁸