Figure 1.

Antitumor effects of helvolic acid (HA) and cyclophosphamide (CTX) in a mouse tumor model. (a) Chemical structure of helvolic acid. (b) Tumors from the indicated treatment groups at euthanasia. (c) Body weights and (d) tumor sizes after tumor inoculation. (e) Tumor weights and (f) body weights at euthanasia. (g) Hematoxylin and eosin-stained tumor tissue sections from the indicated groups. (h) Survival of tumor-burdened mice after the indicated treatments. (♦) MG; (▴) CTX; (□) HA-H; (•) HA-L; (▪) CG; MG, model vehicle control group; CTX, CTX-treated group; HA-H, high-dose helvolic acid; HA-L, low-dose helvolic acid; CG, combination of CTX + HA-L group. *P < 0.05 and **P < 0.01 vs. MG. Scale bar = 50 µm