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. 2016 Nov 14;8(12):1409–1420. doi: 10.15252/emmm.201506035

Figure 2. Local administration of 4‐AP in PLGA films enhances functional and electrophysiological recovery after sciatic nerve crush.

Figure 2

  1. Local 4‐AP‐treated crushed sciatic nerve (dashed line, vehicle PLGA films; solid line, (4‐AP)‐PLGA films) regained partial walking ability as early as 3 days post‐injury compared to vehicle‐treated group. **: D5, P = 0.0004; D8, P = 0.0012; D11, P = 0.003; D14, P = 0.0089; ANOVA with post hoc comparisons using two‐tailed unpaired t‐test. n = 6.
  2. Local 4‐AP‐treated crushed sciatic nerve (dashed line: vehicle PLGA films; solid line: (4‐AP)‐PLGA films) showed faster improvement in NCV restoration compared with vehicle‐treated mice, beginning at 21 days post‐injury. **: D21, P = 0.0002; D28, P = 0.00007; D35, P = 0.00019; ANOVA with post hoc comparisons using two‐tailed unpaired t‐test. n = 5. The figure shows representative outcomes from one of three replicated experiments.
Data information: Data are presented as mean ± SEM and show a representative experiment from 2 to 3 repetitions.